Seurat Cell Categorization
Reha Mathur
importing packages
library("devtools")Loading required package: usethisinstall_github("jw156605/SLICER")Skipping install of 'SLICER' from a github remote, the SHA1 (cb1be8ac) has not changed since last install.
Use `force = TRUE` to force installationlibrary(Seurat)Attaching SeuratObjectlibrary(readr)
library(tidyverse)Registered S3 methods overwritten by 'dbplyr':
method from
print.tbl_lazy
print.tbl_sql ── Attaching packages ─────────────────────────────────────────────────── tidyverse 1.3.2 ──
✔ ggplot2 3.4.0 ✔ dplyr 1.0.10
✔ tibble 3.1.8 ✔ stringr 1.5.0
✔ tidyr 1.2.1 ✔ forcats 0.5.2
✔ purrr 0.3.5
── Conflicts ────────────────────────────────────────────────────── tidyverse_conflicts() ──
✖ dplyr::filter() masks stats::filter()
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library(latticeExtra)Loading required package: lattice
Attaching package: ‘latticeExtra’
The following object is masked from ‘package:ggplot2’:
layerlibrary(lattice)
library(RColorBrewer)
library(clusterProfiler)clusterProfiler v4.4.4 For help: https://yulab-smu.top/biomedical-knowledge-mining-book/
If you use clusterProfiler in published research, please cite:
T Wu, E Hu, S Xu, M Chen, P Guo, Z Dai, T Feng, L Zhou, W Tang, L Zhan, X Fu, S Liu, X Bo, and G Yu. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. The Innovation. 2021, 2(3):100141
Attaching package: ‘clusterProfiler’
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filterlibrary(org.Mm.eg.db)Loading required package: AnnotationDbi
Loading required package: stats4
Loading required package: BiocGenerics
Attaching package: ‘BiocGenerics’
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pmin, pmin.int, Position, rank, rbind, Reduce, rownames, sapply, setdiff,
sort, table, tapply, union, unique, unsplit, which.max, which.min
Loading required package: Biobase
Welcome to Bioconductor
Vignettes contain introductory material; view with 'browseVignettes()'. To
cite Bioconductor, see 'citation("Biobase")', and for packages
'citation("pkgname")'.
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Attaching package: ‘AnnotationDbi’
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selectlibrary(AnnotationDbi)reading in normalized data again
exp = read_csv("normalized_data.csv")New names:
• `` -> `...1`
• `` -> `...151`
• `` -> `...240`
• `` -> `...289`
• `` -> `...352`
• `` -> `...391`
• `` -> `...394`
• `` -> `...450`
• `` -> `...462`
Rows: 14414 Columns: 463
── Column specification ───────────────────────────────────────────────────────────────────────────────────────────────
Delimiter: ","
chr (1): ...1
dbl (454): M1_A01, M1_A02, M1_A03, M1_A05, M1_A06, M1_A08, M1_A09, M1_A10, M1_B01, M1_B03, M1_B04, M1_B05, M1_B06, ...
lgl (8): ...151, ...240, ...289, ...352, ...391, ...394, ...450, ...462
ℹ Use `spec()` to retrieve the full column specification for this data.
ℹ Specify the column types or set `show_col_types = FALSE` to quiet this message.exp = discard(exp,~all(is.na(.) |. == ""))
exp = distinct(exp, `...1`, .keep_all = TRUE)
# filtering out the reprogramming transcription factors
exp = filter(exp, !`...1`%in% c("Mef2c", "Gata4", "Tbx5"))
exp = column_to_rownames(exp, var="...1")
creating a seurat object with all of the cells
seurat.obj = CreateSeuratObject(counts = exp)seurat.obj = NormalizeData(seurat.obj)Performing log-normalization
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[----|----|----|----|----|----|----|----|----|----|
**************************************************|seurat.obj = FindVariableFeatures(seurat.obj, selection.method = "vst", nfeatures = 10000)Calculating gene variances
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Calculating feature variances of standardized and clipped values
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**************************************************|all.genes = rownames(seurat.obj)
seurat.obj = ScaleData(seurat.obj, features = all.genes)Centering and scaling data matrix
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|==================================================================================| 100%seurat.obj = RunPCA(seurat.obj, features = VariableFeatures(seurat.obj))PC_ 1
Positive: Ehd4, Acaa2, Dsp, Ldhb, Nid2, Ryr2, Myl4, Epb4.1, Smpx, Tnni3
Ttn, Tnnt2, Mgst3, Sort1, Ldb3, Jup, Mlf1, Baiap2l1, Rrad, Mgrn1
Fryl, Ppp1r3c, Fam134b, Fabp3, Cenpa, Usp28, Clu, Pcyt1a, Ddit4l, Cd24a
Negative: Fstl1, Bgn, Cd200, Col3a1, Rbp1, Tagln2, Fam198b, Postn, Col1a2, Tagln
Fbln2, Rbms3, Lox, Fbn1, Loxl1, Dhrs3, Marcks, Col8a1, 11-Sep, Col5a2
Clca1, Lrrc8a, Spry2, Anxa1, Ogn, Nars, Gstm2, Fbln5, Asns, Acta2
PC_ 2
Positive: Top2a, Prc1, Smc2, Ccnb1, Birc5, Cdk1, Ube2c, Rrm2, Mki67, Pbk
Ckap2l, Asf1b, Cks2, Tpx2, Cdca8, Kif20b, 2810417H13Rik, Cks1b, Anln, Tacc3
Spc25, Hmmr, Hmgb2, Shcbp1, Ndc80, Mad2l1, Nuf2, Cenpe, Ect2, Cdca2
Negative: Cst3, B2m, Sptbn1, Malat1, Ypel5, Itm2b, Gyg, Parp3, Tspyl1, Serpine2
Lama2, Igfbp7, Ogn, B4galt1, Gpx3, Ctsa, Asah1, Pdcd4, Itgb5, Fhl2
Pam, Col4a2, Lhfp, Tcn2, Mxra8, Smim14, Ctsd, Akap13, Prex2, Impact
PC_ 3
Positive: Cst3, Col4a1, Flna, Igfbp7, Col1a1, Col4a2, Myl9, Sorbs2, Fhl2, Itgb1
Tns1, Col14a1, Ankrd1, Tpm2, Lbh, Pcolce, Tuba1a, Postn, Tuba1b, Itga1
Col5a1, Actn4, Pdlim2, Myom1, Pdgfrb, Tbx20, Sorbs1, Acta2, Pcdh18, Macf1
Negative: Gpm6a, Mgst1, Hpgd, Gsta4, Ptgs1, Upk1b, Pkhd1l1, F11r, Msln, Bst1
Maf, Ezr, Mpzl2, Cxadr, Krt8, Cd55, Igfbp6, Igfbp4, Acsl4, Bex4
Gcnt1, Vnn1, Ftl1, Efna5, Slpi, Ptp4a2, Tmem108, Tmem154, Csde1, Bnc1
PC_ 4
Positive: S100a6, Tpm1, Tpm4, Actb, Nme1, Zyx, Lgals1, Tpm2, Cryab, Actg1
Wisp1, Gapdh, Gm12070, Actn1, Timp1, Slc25a5, Sec13, Eif5a, Psat1, Creb3l1
Tnfrsf12a, Ccnd2, Csf1, Pkm, Pcolce, Acta2, Des, Rcn3, Col1a1, Wdr1
Negative: Egfl7, Ctla2a, Gja4, Emcn, Cdh5, Notch1, Klhl4, Gimap6, Pecam1, Stab1
Gpr116, Lyl1, Tie1, Entpd1, Ctla2b, Fli1, Myct1, Sox7, Thsd1, Eltd1
Gngt2, Mmrn2, S1pr1, Mecom, Tgfbi, Klhl24, Tmem2, Apoe, Plxnd1, Akap13
PC_ 5
Positive: Egfl7, Notch1, Klhl4, Stab1, Cdh5, Emcn, Cgnl1, Pecam1, Gja4, Ramp2
Lyl1, Col4a1, Gpr116, Tie1, Entpd1, Zfp69, Loxl2, Eltd1, Plxnd1, Thsd1
Cxcl16, Col5a1, Tek, S1pr1, Txndc5, Tgfbi, Odc1, Eng, Sox7, Myct1
Negative: Spcs3, Impact, Ypel5, Cpne8, Lnp, Arhgap44, Sptbn1, Myo10, Nexn, Arid5b
Arl5a, Braf, Klhl9, Cpne3, Lama2, Mrfap1, Serping1, Mlf1, Zdhhc2, Mier3
Gm2a, Dstn, Emc2, Myoz2, Ncam1, Rhobtb3, Cryab, Gucy1a3, Ttn, Idh1 ElbowPlot(seurat.obj)
Seurat clustering the entire graph to see what clusters are identified
seurat.obj = FindNeighbors(seurat.obj, dims = 1:15)Computing nearest neighbor graph
Computing SNNseurat.obj = FindClusters(seurat.obj, resolution = 1.75)Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 454
Number of edges: 16805
Running Louvain algorithm...0% 10 20 30 40 50 60 70 80 90 100%
[----|----|----|----|----|----|----|----|----|----|
**************************************************|Maximum modularity in 10 random starts: 0.4797
Number of communities: 8
Elapsed time: 0 secondsimporting the results from the paper and our hierarchical clustering results for further comparison
identified_cells = read.csv("paper_cell_states.csv", row.names = 1, header=TRUE)identified_cells = identified_cells[match(rownames(seurat.obj@meta.data), rownames(identified_cells)),]
seurat.obj@meta.data$cc_paper = identified_cells$CC
seurat.obj@meta.data$cat_paper = identified_cells$stage
seurat.obj@meta.data$cc_hclust = "CCI"
seurat.obj@meta.data[active_cells,]$cc_hclust = "CCA"
Idents(seurat.obj) = "RNA_snn_res.1.75"running UMAP dimensional reduction on the data to plot the data
seurat.obj = RunUMAP(seurat.obj, dims = 1:15)Warning: The default method for RunUMAP has changed from calling Python UMAP via reticulate to the R-native UWOT using the cosine metric
To use Python UMAP via reticulate, set umap.method to 'umap-learn' and metric to 'correlation'
This message will be shown once per session
00:34:45 UMAP embedding parameters a = 0.9922 b = 1.112
00:34:45 Read 454 rows and found 15 numeric columns
00:34:45 Using Annoy for neighbor search, n_neighbors = 30
00:34:45 Building Annoy index with metric = cosine, n_trees = 50
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**************************************************|
00:34:45 Writing NN index file to temp file /var/folders/fj/09brpj8s5mz1c5wxktl80s080000gn/T//RtmpXaF6CV/fileec356c43b603
00:34:45 Searching Annoy index using 1 thread, search_k = 3000
00:34:45 Annoy recall = 100%
00:34:46 Commencing smooth kNN distance calibration using 1 thread with target n_neighbors = 30
00:34:47 Initializing from normalized Laplacian + noise (using irlba)
00:34:47 Commencing optimization for 500 epochs, with 17028 positive edges
Using method 'umap'
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[----|----|----|----|----|----|----|----|----|----|
**************************************************|
00:34:48 Optimization finishedseeing what tsne reduction makes the data do
seurat.obj = RunTSNE(seurat.obj, dims = 1:15)
DimPlot(seurat.obj, reduction = "tsne", group.by = 'RNA_snn_res.1.75')
finding differentially expressed markers in these clusters
markers = FindAllMarkers(seurat.obj, logfc.threshold = 0.25, min.pct = 0.1, only.pos = FALSE, test.use = 'MAST')Calculating cluster 0
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 1
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 2
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 3
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 4
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 5
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 6
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 7
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!top markers for the clusters of all of the cells and violin plots of their expression
top_markers = markers %>%
group_by(cluster) %>%
slice_max(n = 2, order_by = avg_log2FC)VlnPlot(seurat.obj, features = c("Rbp1", "Dhrs3"))
VlnPlot(seurat.obj, features = c("Fstl1", "Bgn"))
VlnPlot(seurat.obj, features = c("Serpinh1", "Dsp"))
VlnPlot(seurat.obj, features = c("Prc1", "Birc5"))
categorizing the cells based off their cell cycle analysis
## cell cycle
s.genes <- str_to_title(cc.genes$s.genes)
g2m.genes <- str_to_title(cc.genes$g2m.genes)
seurat.obj = CellCycleScoring(seurat.obj, s.features = s.genes, g2m.features = g2m.genes)
seurat.obj@meta.data$cat_cluster = cell_categorized$stage
plotting the comparison of the cell cycle results
clusters = DimPlot(seurat.obj, group.by = "RNA_snn_res.1.75", label = TRUE, reduction = "umap")real_condition = DimPlot(seurat.obj, group.by = "cc_paper", label = TRUE, reduction = "umap") phase = DimPlot(seurat.obj, group.by = "Phase", label = TRUE, reduction = "umap") cat = DimPlot(seurat.obj, group.by = "cc_hclust", label = TRUE, reduction = "umap")
clusters|real_condition|cat|phase
NA
NAsubsetting the cells that fit with hclust and performing clustering on each group
#cca_seurat = subset(x = seurat.obj, subset = cc_hclust == "CCA")
#cci_seurat = subset(x = seurat.obj, subset = cc_hclust == "CCI")
cca_seurat = subset(x = seurat.obj, subset = Phase == "S" | Phase == "G2M")
cci_seurat = subset(x = seurat.obj, subset = Phase == "G1")clustering CCI cels
cci_seurat = FindNeighbors(cci_seurat, dims = 1:15)Computing nearest neighbor graph
Computing SNNcci_seurat = FindClusters(cci_seurat, resolution = 1)Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 319
Number of edges: 12257
Running Louvain algorithm...0% 10 20 30 40 50 60 70 80 90 100%
[----|----|----|----|----|----|----|----|----|----|
**************************************************|Maximum modularity in 10 random starts: 0.5331
Number of communities: 4
Elapsed time: 0 secondscl= DimPlot(cci_seurat, group.by = "RNA_snn_res.1",label = TRUE)pap = DimPlot(cci_seurat, group.by = "cat_paper", label = TRUE)hgc = DimPlot(cci_seurat, group.by = "cat_cluster", label = TRUE)
cl|pap|hgc
identifying CCI cells
cci_markers = FindAllMarkers(cci_seurat, logfc.threshold = 0.25, min.pct = 0.1, only.pos = FALSE, test.use = 'MAST')Calculating cluster 0
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 1
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 2
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 3
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
Completed [==>-----------------------------------------------------] 6% with 0 failures
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Done!cci_top_markers = cci_markers %>%
group_by(cluster) %>%
slice_min(n = 5, order_by = p_val_adj)VlnPlot(cci_seurat, features = c("Fstl1", "Bgn"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Tnni3", "Smpx"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Vcam1", "Tm4sf1"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Clca2", "Cd200"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Lox", "Tm4sf1"), cols = c("purple", "light green", "red", "blue"))
Fstl1 involved in endothelial cell differentiation and endothelial cell migration and Bgn is a gene that is used for connective tissue metabolism -> lower expression -> cluster 1 = iCM, cluster 2 likely pICM
Tnni3, smpx, dsp used for cardiomycoytes -> cluster 2 = pre-iCM, cluster 1 and 3 are still fibroblasts
Idents(cci_seurat) = "RNA_snn_res.1"
cci_seurat = RenameIdents(cci_seurat, `0` = "0")
cci_seurat = RenameIdents(cci_seurat, `1` = "iCM")
cci_seurat = RenameIdents(cci_seurat, `2` = "piCM")
cci_seurat = RenameIdents(cci_seurat, `3` = "3")
cl= DimPlot(cci_seurat, label = TRUE, cols = c("purple", "light green", "red", "blue"))pap = DimPlot(cci_seurat, group.by = "cat_paper", label = TRUE, cols = c("blue", "red", "purple", "light green"))hgc = DimPlot(cci_seurat, group.by = "cat_cluster", label = TRUE, cols = c("blue", "red", "purple", "light green"))
cl|pap|hgc
clustering CCA cells
cca_seurat = FindNeighbors(cca_seurat, dims = 1:15)Computing nearest neighbor graph
Computing SNNcca_seurat = FindClusters(cca_seurat, resolution = 1)Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 135
Number of edges: 4159
Running Louvain algorithm...0% 10 20 30 40 50 60 70 80 90 100%
[----|----|----|----|----|----|----|----|----|----|
**************************************************|Maximum modularity in 10 random starts: 0.4323
Number of communities: 4
Elapsed time: 0 secondscl= DimPlot(cca_seurat, group.by = "RNA_snn_res.1",label = TRUE)pap = DimPlot(cca_seurat, group.by = "cat_paper", label = TRUE)cl|pap
identifying CCA cells
cca_markers = FindAllMarkers(cca_seurat, logfc.threshold = 0.25, min.pct = 0.1, only.pos = FALSE, test.use = 'MAST')Calculating cluster 0
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 1
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 2
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Done!
Combining coefficients and standard errors
Calculating log-fold changes
Calculating likelihood ratio tests
Refitting on reduced model...
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Done!
Calculating cluster 3
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Combining coefficients and standard errors
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Done!cca_top_markers = cca_markers %>%
group_by(cluster) %>%
slice_min(n = 5, order_by = p_val_adj)
VlnPlot(cca_seurat, features = c("Fstl1", "Bgn"), cols = c("blue", "purple", "light green", "red"))
VlnPlot(cca_seurat, features = c("Tnni3", "Smpx"), cols = c("blue", "purple", "light green", "red"))
VlnPlot(cca_seurat, features = c("Vcam1", "Tm4sf1"), cols = c("blue", "purple", "light green", "red"))
VlnPlot(cca_seurat, features = c("Clca2", "Cd200"), cols = c("blue", "purple", "light green", "red"))
NA
NATnni3 related to heart fucntion -> iCM= 2
Idents(cca_seurat) = "RNA_snn_res.1"
cca_seurat = RenameIdents(cca_seurat, `2` = "iCM")
cca_seurat = RenameIdents(cca_seurat, `1` = "1")
cca_seurat = RenameIdents(cca_seurat, `0` = "0")
cca_seurat = RenameIdents(cca_seurat, `3` = "3")
cl= DimPlot(cca_seurat, label = TRUE,cols = c("blue", "purple", "light green", "red"))pap = DimPlot(cca_seurat, group.by = "cat_paper", label = TRUE, cols = c("blue", "red", "purple", "light green"))hgc = DimPlot(cca_seurat, group.by = "cat_cluster", label = TRUE, cols = c("blue", "red", "purple", "light green"))cl|pap|hgc
Trying out SCTransform which is supposedly better for single cell data
seurat.sc = CreateSeuratObject(counts = exp)
seurat.sc = SCTransform(seurat.sc)Calculating cell attributes from input UMI matrix: log_umi
Variance stabilizing transformation of count matrix of size 14028 by 454
Model formula is y ~ log_umi
Get Negative Binomial regression parameters per gene
Using 2000 genes, 454 cells
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|==================================================================================| 100%Calculating gene attributes
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Determine variable features
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Set default assay to SCTseurat.sc = RunPCA(seurat.sc, features = VariableFeatures(seurat.sc))PC_ 1
Positive: Bgn, Fstl1, Postn, Col1a2, Cd200, Col3a1, Rbp1, Tagln, Dhrs3, Tagln2
Acta2, 11-Sep, Fbln2, Clca1, Lox, Wisp2, Col8a1, Anxa1, Fam198b, Marcks
Ogn, Col5a2, Fbn1, Pdpn, Asns, Adamts5, Acot2, Irgm1, Tcf21, Ptprb
Negative: Tnnt2, Nid2, Acaa2, Myl4, Ldhb, Dsp, Ehd4, Clu, Tnni3, Smpx
Ttn, Ryr2, Myl7, Cd24a, Gpx3, Epb4.1, Fam134b, Ppp1r3c, Sort1, Mgrn1
Mlf1, Rn45s, Ldb3, Cenpa, Rrad, Fabp3, Arhgap44, Mgst3, Lgals3, Ptrf
PC_ 2
Positive: Top2a, Smc2, Ccnb1, Cdk1, Prc1, Mki67, Rrm2, H2afz, Stmn1, Tpx2
Cdca8, Anln, Pbk, Birc5, Tacc3, Ckap2l, Asf1b, Mad2l1, Hmgn2, Hmmr
Ube2c, Rrm1, Cenpe, Kif20b, Cks2, Ndc80, Shcbp1, Spc25, Hmgb2, Cdca3
Negative: Cst3, Gyg, Malat1, Gpx3, Sptbn1, B2m, Ogn, Fhl2, Sparc, Dhrs3
Serpine2, Tnnt2, Impact, Rbp1, Col5a2, Sat1, Fn1, Itgb5, B4galt1, Col4a2
Serpina3h, Lama2, Tmsb4x, Postn, Gucy1a3, Adamtsl2, Hsd11b1, Adamts5, Ttyh2, Myl9
PC_ 3
Positive: Mgst1, Pdpn, Vcam1, Ftl1, F11r, Efna5, Cyp1b1, Sdc4, Ptgs1, Gpm6a
Steap1, Ezr, Upk1b, Ctsl, Dcn, Ccl2, Gsta4, Maf, Flrt2, Msln
Efemp1, Timp3, Igfbp4, Cxadr, Hpgd, Dpp4, Gja1, Mpzl2, F3, Bnc1
Negative: Myl9, Ankrd1, Acta2, Cst3, Sorbs2, Tnnt2, Fhl2, Mustn1, Tmsb4x, Flna
Pdlim3, Lmcd1, Tagln, Col4a1, Pls3, Lpp, Postn, Wisp2, Gyg, Gpx3
Sh3bgrl, Myl4, Col4a2, Itga8, Pdlim2, Fn1, Nid2, Vim, Myom1, Csrp2
PC_ 4
Positive: Tpm1, Acta2, Tagln, Anxa1, Actg1, Actb, Cav1, Anxa2, Myl9, Tmsb4x
Prss23, Efemp1, Cryab, Mustn1, Zyx, Flna, Arl5a, Lox, S100a4, Col8a1
Spcs3, Thbs1, Pls3, Fhl1, Ccnd2, Upk1b, Lpp, Map6, Plec, Ankrd1
Negative: Dcn, Abcg1, Rbp1, B2m, Igf2r, Hsd11b1, Gpx3, B4galt1, Mmp2, Mgp
Serpine2, Cxcl1, Serpina3g, Cp, Angptl2, Ttyh2, Serpina3h, Rab31, Ccl7, Serpina3n
Tmem176b, Srpx2, Gpm6b, Sepp1, Ctsl, Btg2, Ccl2, Btg1, Dhrs3, Casp4
PC_ 5
Positive: Serpina3h, Col1a2, Col1a1, Serpina3i, Col4a1, Lsp1, Csf1, Ch25h, Asns, Des
Ccl7, Wisp1, Col6a3, Adamtsl2, Gfpt2, Lgals1, Timp1, Serpina3g, Psat1, Ankrd1
Col4a2, Nars, Flnb, Pcolce, Postn, Chst11, Ccnd1, Ckb, Rn45s, Flna
Negative: Spcs3, Sptbn1, Btg1, Impact, Phactr2, Akap13, Rab31, Cd93, Cfh, Slc38a2
Myo10, Arl5a, Sh3bgrl, Adamts5, Ddah1, Tspan12, Fryl, Gucy1a3, Lmcd1, Canx
Id3, Adamtsl3, Prss23, Eln, Clca1, B230120H23Rik, 5430417L22Rik, Wisp2, AI597468, Fn1 identified_cells = identified_cells[match(rownames(seurat.sc@meta.data), rownames(identified_cells)),]
seurat.sc@meta.data$cc_paper = identified_cells$CC
seurat.sc@meta.data$cat_paper = identified_cells$stage
seurat.sc = RunUMAP(seurat.sc, dims = 1:15)Warning: The default method for RunUMAP has changed from calling Python UMAP via reticulate to the R-native UWOT using the cosine metric
To use Python UMAP via reticulate, set umap.method to 'umap-learn' and metric to 'correlation'
This message will be shown once per session
12:32:25 UMAP embedding parameters a = 0.9922 b = 1.112
12:32:25 Read 454 rows and found 15 numeric columns
12:32:25 Using Annoy for neighbor search, n_neighbors = 30
12:32:25 Building Annoy index with metric = cosine, n_trees = 50
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[----|----|----|----|----|----|----|----|----|----|
**************************************************|
12:32:25 Writing NN index file to temp file /var/folders/fj/09brpj8s5mz1c5wxktl80s080000gn/T//Rtmp8VGprm/file153ed68dea2d5
12:32:25 Searching Annoy index using 1 thread, search_k = 3000
12:32:25 Annoy recall = 100%
12:32:25 Commencing smooth kNN distance calibration using 1 thread with target n_neighbors = 30
12:32:26 Initializing from normalized Laplacian + noise (using irlba)
12:32:26 Commencing optimization for 500 epochs, with 17490 positive edges
Using method 'umap'
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[----|----|----|----|----|----|----|----|----|----|
**************************************************|
12:32:27 Optimization finishedseurat.sc = FindNeighbors(seurat.sc, dims = 1:15)Computing nearest neighbor graph
Computing SNNseurat.sc = FindClusters(seurat.sc, resolution = 1.75)Modularity Optimizer version 1.3.0 by Ludo Waltman and Nees Jan van Eck
Number of nodes: 454
Number of edges: 15941
Running Louvain algorithm...0% 10 20 30 40 50 60 70 80 90 100%
[----|----|----|----|----|----|----|----|----|----|
**************************************************|Maximum modularity in 10 random starts: 0.4966
Number of communities: 8
Elapsed time: 0 secondsseurat.sc = CellCycleScoring(seurat.sc, s.features = s.genes, g2m.features = g2m.genes)clusters = DimPlot(seurat.sc, group.by = "SCT_snn_res.1.75", label = TRUE, reduction = "umap")real_condition = DimPlot(seurat.sc, group.by = "cc_paper", label = TRUE, reduction = "umap") phase = DimPlot(seurat.sc, group.by = "Phase", label = TRUE, reduction = "umap") cat = DimPlot(seurat.sc, group.by = "cat_paper", label = TRUE, reduction = "umap")
clusters|real_condition|phase|cat
The results are largely the same so just going to continue on with the original clsutering.
---
title: "Seurat Cell Categorization"
author: "Reha Mathur"
output: html_notebook
---
## importing packages 
```{r}
library("devtools")
install_github("jw156605/SLICER")
library(Seurat)
library(readr)
library(tidyverse)
library(HGC) 
library(latticeExtra)
library(lattice) 
library(RColorBrewer)
library(clusterProfiler)
library(org.Mm.eg.db)
library(AnnotationDbi)
```
## reading in normalized data again
```{r}
exp = read_csv("normalized_data.csv")
exp = discard(exp,~all(is.na(.) |.  == ""))
exp = distinct(exp, `...1`, .keep_all = TRUE)
# filtering out the reprogramming transcription factors 
exp = filter(exp, !`...1`%in% c("Mef2c", "Gata4", "Tbx5"))
exp = column_to_rownames(exp, var="...1")

```
## creating a seurat object with all of the cells 

```{r}
seurat.obj = CreateSeuratObject(counts = exp)
```
```{r}
# using seurat to noramlize, scale and dimensionally reduce the data 
seurat.obj = NormalizeData(seurat.obj)
seurat.obj = FindVariableFeatures(seurat.obj, selection.method =  "vst", nfeatures = 10000)
all.genes = rownames(seurat.obj)
seurat.obj = ScaleData(seurat.obj, features = all.genes)
seurat.obj = RunPCA(seurat.obj, features =  VariableFeatures(seurat.obj))

```
```{r}
# elbow plot to see the correct number of dimensions
ElbowPlot(seurat.obj)
```
## Seurat clustering the entire graph to see what clusters are identified 
```{r}
seurat.obj = FindNeighbors(seurat.obj, dims = 1:15)
```

```{r}
seurat.obj = FindClusters(seurat.obj, resolution = 1.75)
```
## importing the results from the paper and our hierarchical clustering results for further comparison
```{r}
identified_cells = read.csv("paper_cell_states.csv", row.names = 1, header=TRUE)
```
```{r}
identified_cells = identified_cells[match(rownames(seurat.obj@meta.data), rownames(identified_cells)),]
seurat.obj@meta.data$cc_paper = identified_cells$CC
seurat.obj@meta.data$cat_paper = identified_cells$stage
seurat.obj@meta.data$cc_hclust = "CCI"
seurat.obj@meta.data[active_cells,]$cc_hclust = "CCA"

```


```{r}
Idents(seurat.obj)  = "RNA_snn_res.1.75"
```
## running UMAP dimensional reduction on the data to plot the data 
```{r}
seurat.obj = RunUMAP(seurat.obj, dims = 1:15)
```
# seeing what tsne reduction makes the data do 
```{r}
seurat.obj = RunTSNE(seurat.obj, dims = 1:15)
DimPlot(seurat.obj, reduction = "tsne", group.by = 'RNA_snn_res.1.75')
``` 
# finding differentially expressed markers in these clusters
```{r}
markers = FindAllMarkers(seurat.obj, logfc.threshold =  0.25, min.pct = 0.1, only.pos = FALSE, test.use = 'MAST')
```
# top markers for the clusters of all of the cells and violin plots of their expression 
```{r}
top_markers = markers %>%
    group_by(cluster) %>%
    slice_max(n = 2, order_by = avg_log2FC)
```

```{r}
VlnPlot(seurat.obj, features = c("Rbp1", "Dhrs3"))
VlnPlot(seurat.obj, features = c("Fstl1", "Bgn"))
VlnPlot(seurat.obj, features = c("Serpinh1", "Dsp"))
VlnPlot(seurat.obj, features = c("Prc1", "Birc5"))
```
## categorizing the cells based off their cell cycle analysis 
```{r}
## cell cycle 
s.genes <- str_to_title(cc.genes$s.genes)
g2m.genes <- str_to_title(cc.genes$g2m.genes)

seurat.obj = CellCycleScoring(seurat.obj, s.features = s.genes, g2m.features = g2m.genes)
seurat.obj@meta.data$cat_cluster = cell_categorized$stage

```

## plotting the comparison of the cell cycle results
```{r}
clusters = DimPlot(seurat.obj, group.by = "RNA_snn_res.1.75", label = TRUE, reduction = "umap")
real_condition = DimPlot(seurat.obj, group.by = "cc_paper", label = TRUE, reduction = "umap") 
phase = DimPlot(seurat.obj, group.by = "Phase", label = TRUE, reduction = "umap") 
cat = DimPlot(seurat.obj, group.by = "cc_hclust", label = TRUE, reduction = "umap")

clusters|real_condition|cat|phase


```



## subsetting the cells that fit with hclust and performing clustering on each group 

```{r}
#cca_seurat = subset(x = seurat.obj, subset = cc_hclust == "CCA")
#cci_seurat = subset(x = seurat.obj, subset = cc_hclust == "CCI")
cca_seurat = subset(x = seurat.obj, subset = Phase == "S" | Phase == "G2M")
cci_seurat = subset(x = seurat.obj, subset = Phase == "G1")
```

## clustering CCI cels 

```{r}
cci_seurat = FindNeighbors(cci_seurat, dims = 1:15)
cci_seurat = FindClusters(cci_seurat, resolution = 1)
```

```{r}
cl= DimPlot(cci_seurat, group.by = "RNA_snn_res.1",label = TRUE)
pap = DimPlot(cci_seurat, group.by = "cat_paper", label = TRUE)
hgc = DimPlot(cci_seurat, group.by = "cat_cluster", label = TRUE)

cl|pap|hgc
```
## identifying CCI cells 

```{r}
cci_markers = FindAllMarkers(cci_seurat, logfc.threshold =  0.25, min.pct = 0.1, only.pos = FALSE, test.use = 'MAST')
```
```{r}
cci_top_markers = cci_markers %>%
    group_by(cluster) %>%
    slice_min(n = 5, order_by = p_val_adj)
```

```{r}
VlnPlot(cci_seurat, features = c("Fstl1", "Bgn"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Tnni3", "Smpx"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Vcam1", "Tm4sf1"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Clca2", "Cd200"), cols = c("purple", "light green", "red", "blue"))
VlnPlot(cci_seurat, features = c("Lox", "Tm4sf1"), cols = c("purple", "light green", "red", "blue"))

```

Fstl1 involved in endothelial cell differentiation and endothelial cell migration and Bgn is a gene that is used for connective tissue metabolism -> lower expression -> cluster 1 = iCM, cluster 2 likely pICM

Tnni3, smpx, dsp used for cardiomycoytes -> cluster 2 = pre-iCM, cluster 1 and 3 are still fibroblasts 

```{r}
Idents(cci_seurat)  = "RNA_snn_res.1"
cci_seurat = RenameIdents(cci_seurat, `0` = "0")
cci_seurat = RenameIdents(cci_seurat, `1` = "iCM")
cci_seurat = RenameIdents(cci_seurat, `2` = "piCM")
cci_seurat = RenameIdents(cci_seurat, `3` = "3")

```

```{r}
cl= DimPlot(cci_seurat, label = TRUE, cols = c("purple", "light green", "red", "blue"))
pap = DimPlot(cci_seurat, group.by = "cat_paper", label = TRUE, cols = c("blue", "red", "purple", "light green"))
hgc = DimPlot(cci_seurat, group.by = "cat_cluster", label = TRUE, cols = c("blue", "red", "purple", "light green"))

cl|pap|hgc
```
## clustering CCA cells

```{r}
cca_seurat = FindNeighbors(cca_seurat, dims = 1:15)
cca_seurat = FindClusters(cca_seurat, resolution = 1)
```

```{r}
cl= DimPlot(cca_seurat, group.by = "RNA_snn_res.1",label = TRUE)
pap = DimPlot(cca_seurat, group.by = "cat_paper", label = TRUE)
cl|pap
```
## identifying CCA cells 

```{r}
cca_markers = FindAllMarkers(cca_seurat, logfc.threshold =  0.25, min.pct = 0.1, only.pos = FALSE, test.use = 'MAST')
```
```{r}
cca_top_markers = cca_markers %>%
    group_by(cluster) %>%
    slice_min(n = 5, order_by = p_val_adj)
```

```{r}
VlnPlot(cca_seurat, features = c("Fstl1", "Bgn"), cols = c("blue", "purple", "light green", "red"))
VlnPlot(cca_seurat, features = c("Tnni3", "Smpx"), cols = c("blue", "purple", "light green", "red"))
VlnPlot(cca_seurat, features = c("Vcam1", "Tm4sf1"), cols = c("blue", "purple", "light green", "red"))
VlnPlot(cca_seurat, features = c("Clca2", "Cd200"), cols = c("blue", "purple", "light green", "red"))
```
#### 

Tnni3 related to heart fucntion -> iCM= 2 

```{r}
Idents(cca_seurat)  = "RNA_snn_res.1"
cca_seurat = RenameIdents(cca_seurat, `2` = "iCM")
cca_seurat = RenameIdents(cca_seurat, `1` = "1")
cca_seurat = RenameIdents(cca_seurat, `0` = "0")
cca_seurat = RenameIdents(cca_seurat, `3` = "3")
```

```{r}
cl= DimPlot(cca_seurat, label = TRUE,cols = c("blue", "purple", "light green", "red"))
pap = DimPlot(cca_seurat, group.by = "cat_paper", label = TRUE, cols = c("blue", "red", "purple", "light green"))
hgc = DimPlot(cca_seurat, group.by = "cat_cluster", label = TRUE, cols = c("blue", "red", "purple", "light green"))
cl|pap|hgc

```

## Trying out SCTransform which is supposedly better for single cell data
```{r}
seurat.sc = CreateSeuratObject(counts = exp)
seurat.sc = SCTransform(seurat.sc)
```
```{r}
seurat.sc = RunPCA(seurat.sc, features =  VariableFeatures(seurat.sc))
```

```{r}
identified_cells = identified_cells[match(rownames(seurat.sc@meta.data), rownames(identified_cells)),]
seurat.sc@meta.data$cc_paper = identified_cells$CC
seurat.sc@meta.data$cat_paper = identified_cells$stage

seurat.sc = RunUMAP(seurat.sc, dims = 1:15)
seurat.sc = FindNeighbors(seurat.sc, dims = 1:15)
seurat.sc = FindClusters(seurat.sc, resolution = 1.75)
```

```{r}
seurat.sc = CellCycleScoring(seurat.sc, s.features = s.genes, g2m.features = g2m.genes)
```

```{r}
clusters = DimPlot(seurat.sc, group.by = "SCT_snn_res.1.75", label = TRUE, reduction = "umap")
real_condition = DimPlot(seurat.sc, group.by = "cc_paper", label = TRUE, reduction = "umap") 
phase = DimPlot(seurat.sc, group.by = "Phase", label = TRUE, reduction = "umap") 
cat = DimPlot(seurat.sc, group.by = "cat_paper", label = TRUE, reduction = "umap") 

clusters|real_condition|phase|cat

```

The results are largely the same so just going to continue on with the original clsutering. 